Music is a fundamental attribute of the human species. Virtually all cultures, from the most primitive to the most advanced, make music. It’s been true through history, and it’s true throughout an individual’s lifespan. In tune or not, we humans sing and hum; in time or not, we clap and sway; in step or not, we dance and bounce.

The human brain and nervous system are hard-wired to distinguish music from noise and to respond to rhythm and repetition, tones and tunes. Is this a biologic accident, or does it serve a purpose? It’s not possible to say. Still, a varied group of studies suggests that music may enhance human health and performance.

From there, things get even more complicated. Studies using MRI and positron emission tomography (PET) scans suggest that nerve networks in different parts of the brain bear primary responsibility for decoding and interpreting various properties of music. For example, a small area in the right temporal lobe is essential to perceive pitch, which forms the basis of melody (patterns of pitch over time), chords (several pitches that sound at the same time), and harmony (two or more melodies at the same time). Another nearby center is responsible for decoding timbre, the quality that allows the brain to distinguish between different instruments that are playing the same note. A different part of the brain, the cerebellum, processes rhythm, and the frontal lobes interpret the emotional content of music. And music that’s powerful enough to be “spine-tingling” can light up the brain’s “reward center,” much like pleasurable stimuli ranging from alcohol to chocolate.

Although every healthy human brain can perform all the complex tasks needed to perceive music, musicians’ brains are, so to speak, more finely attuned to these tasks. At the other end of the spectrum, patients with brain damage may display remarkable defects in musicality; the noted neurologist and writer Dr. Oliver Sacks discusses many fascinating varieties of amusia in his book Musicophilia

The neurobiology of music is a highly specialized field. But music also has major effects on many aspects of health, ranging from memory and mood to cardiovascular function and athletic performance.